The research progress of GATA6 in heart development and isolated atrial septal defect

VernacularTitle:转录因子GATA6在心脏发育以及先天性房间隔缺损中的作用研究进展
Author: Xicai XU ; Fen LI ; Wanping ZHOU ; Diqi ZHU ; Wei JI ; Jingjing HU ; Yiwei CHEN ; Yijiao QIAN ; Ke DAI
Publication Type:Journal Article
Keywords: GATA6; heart development; atrial septal defect
From: Journal of Clinical Pediatrics 2015;(4):380-382
CountryChina
Language:Chinese
Abstract: GATA6 transcription factor belongs to the GATA family and contains 2 conserved zinc ifnger DNA binding domains. GATA6 not only presents in embryonic tissues but also found in heart, lung and pancreas and is essential for the maintenance of their function.The present review focuses on the critical roles of GATA6 in heart development and atrial septal defect to provide theoretical basis for diagnosis and treatment of atrial septal defect.