Relationship between PARVB rs5764455 polymorphism and non-alcoholic fatty liver disease
10.3969/j.issn.1006-5725.2015.09.015
- VernacularTitle:PARVB基因rs5764455多态性与青岛汉族人群非酒精性脂肪性肝病遗传易感性的相关性
- Author:
Ning GENG
;
Man JIANG
;
Jian WANG
;
Yang LIU
;
Xiangjun JIANG
;
Yongning XIN
- Publication Type:Journal Article
- Keywords:
Fatty liver;
Non-alcoholic fatty liver disease;
Gene polymorphism;
PARVB
- From:
The Journal of Practical Medicine
2015;(9):1434-1438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between (beta-parvin) PARVB gene rs5764455 polymorphism and susceptibility to non-alcoholic fatty liver disease (NAFLD). Methods A total of 230 patients with NAFLD (NAFLD, n = 230) and 230 control subjects (control, n = 330) were genotyped by PCR and direct sequencing. Clinical information was detected and compared in different groups. Genotypic frequency and gene frequency distribution in the two groups and relative risks to NAFLD susceptibility were assessed statistically , respectively. Results No statistical differences were observed between PARVB gene rs5764455 genotypic frequency with gene frequency distribution and the two groups, respectively (Genotypic frequency χ2 = 0.182, P = 0.913; gene frequency χ2 = 0.180, P = 0.672). Comparing C/T + T/T genotype carrier with C/C genotype carrier, there were no differences concerning the relative risks to NAFLD susceptibility (OR = 1.266, P =0.178;adjusted OR =1.631, P =0.096) before and after adjusting body mass, BMI and so on. In the latter group, there are significant differences in the increases of body mass, BMI, TG, ALT and AST (P < 0.05). Conclusion Non-relationship was observed between PARVB gene rs5764455 polymorphism and the risk of NAFLD in Qingdao Han Chinese.
