Polyvinyl butyral improves the properties of 3-dimensional nano-zirconia porous scaffolds for bone tissue engineering
- VernacularTitle:聚乙烯醇缩丁醛对三维联通纳米氧化锆骨组织工程支架压缩强度的影响
- Author:
Ruiqiao ZHU
;
Juan MA
;
Yinglan ZHU
;
Xiaolei SHI
;
Zhen DONG
;
Lei JIN
- Publication Type:Journal Article
- Keywords:
Polyvinyl butyral;
Zirconia;
Bone tissue engineering scaffold
- From:
Journal of Medical Postgraduates
2015;(5):521-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective The nano-zirconia scaffolds we previously prepared had a good 3-dimensional ( 3D ) connectivity but did not achieve the ideal sintering rate and compressive strength .The objective of this study was to explore the enhancing effect of polyvinyl butyral ( PVB) as a dispersant on the compressive strength of 3D nano-zirconia porous scaffolds for bone tissue engineering . Methods We prepared the slurry containing different concentrations of PVB and ana-lyzed the improving effect of PVB on the mechanical properties of the scaffolds by sediment experiment , compressive strength test and scan-ning electron microscopy . Results The sediment experiment showed
no significant stratification in the slurry with 0.2wt%PVB, white suspension in the upper layer and white precipitate in the lower layer , with a significantly higher compressive strength of the scaffold ([0.324 ±0.030] MPa) than that of the scaffold prepared by adding other concentrations of PVB to the slurry (P <0.01).And the compressive strength of the scaffold constructed by adding no dispersant ([0.109 ±0.021] MPa) was remarkably lower than that of the scaffold constructed by adding PVB to the slurry (P<0.05).Scanning electron microscopy demonstrated that the scaffold prepared by adding 0.2wt%PVB to the slurry had a complete porous structure with the fewest and most sparsely distributed surface cracks as compared with other PVB concentration groups . Conclusion PVB can signifi-cantly improve the stability of zirconia slurry , enhance the compressive strength of the nano-zirconia porous scaffold , and make the scaf-fold more applicable to bone tissue engineering .
