Study on relationship of blood NF-κB level with metabolic syndrome among rural residents in Ningxia

VernacularTitle:宁夏农村居民全血核转录因子-κB 蛋白与代谢综合征的相关性分析
Author: Weihong WANG ; Jianjun YANG ; Qizhong CHEN
Publication Type:Journal Article
Keywords: Nuclear factor-κB(NF-κB); Metabolic syndrome(MS); Correlation
From: Chinese Journal of Diabetes 2015;(5):397-399
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation of nuclear factor‐κB (NF‐κB) with metabolic syndrome(MS). Methods A total of 240 subjects living in rural areas of Ningxia were enrolled in this study and divided into two groups :MS group (n= 120 ) and healthy control group (n= 120 ). The relationship of NF‐κB with MS was evaluated by t‐test ,partial correlation and conditional logistic regression analysis. Results Whole blood NF‐κB protein level was significantly lower in MS group than in control group [(352.31 ± 307.35) vs (441.00 ± 345.10) ng/L ,P<0.05]. Whole blood NF‐κB protein level was significantly lower in male ,Han nationality ,and 45~55 years old patients of MS group than in control group (P<0.05). Partial correlation analysis showed that NF‐κB was associated with BMI (β=-0.146 ,P=0.025) .Conditional logistic regression analysis showed that whole blood NF‐κB protein was a protective factor for MS (OR=0.91 ,95% CI:0.72~0.98 ,P<0.05). Conclusion The blood NF‐κB level is associated with MS.