Preparation of calcium titanate coating on titanium and its biosafety
- VernacularTitle:钛表面钛酸钙涂层的制备及其生物安全性能的初步研究
- Author:
Chunfeng WANG
;
Min SUN
;
Zhanao WU
;
Xiaoliang WU
;
Tao JIANG
- Publication Type:Journal Article
- Keywords:
Calcium titanate;
Biological material;
Mieronueleus test;
Hemolysis test in vitro
- From:
Journal of Medical Postgraduates
2015;(5):480-485
- CountryChina
- Language:Chinese
-
Abstract:
requirement of medical materials for hemolysis experiment (<5%) .MTT assay showed that , after 4 days of culture , the optical densi-ties were 0.498 ±0.218 and 0.566 ±0.266 in the 120℃12 h and 24 h groups and 0.668 ±0.268 and 0.769 ±0.213 in the 150℃12 h and 24 h groups, while after 8 days, the optical densities were 0.767 ±0.267 and 0.836 ±0.236 in the 120℃12 h and 24 h groups and 0.765 ±0.265 and 0.903 ±0.303 in the 150℃12 h and 24 h groups, all significantly higher than in the non-CaTiO3 group at 4 (0.341 ±0.143) and 8 days (0.731 ±0.121) (P<0.05). Conclusion The CaTiO3 coating on titanium is neither mutagenic nor hemolytic and has no toxicity on osteoblasts .Instead, it can promote the proliferation of osteoblasts , and therefore is a valuable coating material for implants .
