Effects of breviscapine on myocardial ischemia-reperfusion injury in patients undergoing cardiac valve re-placement with cardiopulmonary bypass
- VernacularTitle:灯盏花素对心肺转流瓣膜置换术患者心肌缺血-再灌注损伤的影响
- Author:
Ying ZHOU
;
Guoli LI
;
Jinliang TENG
- Publication Type:Journal Article
- Keywords:
Breviscapine;
Cardiopulmonary bypass;
Superoxide dismutase;
Myocardial ischemia-reperfusion injury
- From:
Journal of Medical Postgraduates
2015;(5):517-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective Cardiac valve replacement with cardiopulmonary bypass ( CPB ) can induce myocardial ischemia-reperfusion injury , which is bad for cardiac function recovery .The aim of the study was to evaluate the myocardial ischemia-reperfusion injury effect of breviscapine intravenously injected before CPB in patients undergoing cardiac valve replacement with CPB . Methods 40 patients scheduled for cardiac valve replacement were randomly divided into two groups :control group and breviscapine group ( n=20).Normal saline 15 mL and breviscapine 0.75 mg/kg was administered with pump within 30 mins after the induction of anesthesia in control group and breviscapine group respectively .Blood samples were taken from jugular vein at each of the five time points: before surgical incision (T0) and at 30mins, at 6, 12, 24h after aortic unclamping (T1-T4) for determination of plasma concentration of car-diac troponin-I (cTnI), creatine kinase isoenzyme (CK-MB) and superoxide dismutase (SOD). Results Compared with T0, the cTnI and CK-MB in both groups significantly increased at T 1-T4 and peaked at T 2 , the SOD in both groups significantly decreased at T 1-T4(P<0.05).Compared with control group, cTnI and CK-MB significantly decreased, while SOD activity significantly increased at T1-T4in breviscapine group (P<0.05). Conclusion The intravenous infusion of breviscapine 0.75 mg/kg before the staring of CPB can relieve myocardial ischemia-reperfusion injury in patients undergoing cardiac valve replacement with CPB , and the mechanism may be related to the anti-oxidative stress effect .
