Research progress on the intracellular mechanisms of kallikrein-kinin system
- VernacularTitle:激肽释放酶-激肽系统的细胞内作用机制研究进展
- Author:
Ruifeng SHI
;
Renliang ZHANG
- Publication Type:Journal Article
- Keywords:
Bradykinin;
Tissue kallikrein;
Mitogen activated protein kinase;
Glycogen synthase kinase-3β;
Nitric oxide
- From:
Journal of Medical Postgraduates
2015;(5):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Kallikrein-kinin system consists of kininogen , kallikrein, bradykinin and kinin .Kinins, derived from kininogen by tissue kallikrein , play their biological effects via bradykinin 1/2 receptors or protease activated receptors .Existing researches suggest that kinins exert various effects through different intracellular and mitochondrial signal pathways such as MAPK , PI3K/Akt/GSK3 be-ta, NO, JAKs/STATs.This review aims to elucidate the roles and the intracellular signal pathways of KKS in different diseases .
