The relationship of serum C-peptide levels and microvascular complications in type 2 diabetes mellitus

VernacularTitle:血清 C 肽水平变化与2型糖尿病微血管病变的相关性研究
Author: Lihua ZHAO ; Jing MA ; Yun XIE
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Chronic kidney disease (CKD ) in diabetes; Diabetic retinopathy (DR); C-peptide(C-P)
From: Chinese Journal of Diabetes 2015;(5):430-433
CountryChina
Language:Chinese
Abstract: Objective To evaluate the relationship between serum C‐P levels and microvascular complications in patients with T 2DM. Methods The clinical data of 434 patients with T2DM were retrospectively analyzed. All subjects were divided into three groups based on ΔC‐P (2 hC‐P - FC‐P) tertiles :ΔC‐P1(≤2.2 ng/ml) ,ΔC‐P2(2.3~4.0 ng/ml) and ΔC‐P3(≥4.1 ng/ml). Results The levels of BMI ,TG ,FC‐P were lower ,and the course and HbAl c were higher in ΔC‐P1 group. ΔC‐P level was positively associated with BMI and TG (P< 0.05) ,and negatively associated with prevalence of DR and chronic kidney disease (CKD)in diabetes ,course and HbA1 c.ΔC‐P levels decreased gradually with the progression of DR and CKD. Logistic regression analysis showed that lower ΔC‐P level was the independent risk factor for microvascular complications after adjustment for related risk factors. Conclusion Serum ΔC‐P level is an independent factor for the development of diabetic microvasculr complications in T 2DM.