Analysis of the related risk factors for neuropathic pain in diabetic rats
10.3969/j.issn.1006-6187.2015.05.020
- VernacularTitle:糖尿病大鼠神经病理性疼痛的相关危险因素的分析
- Author:
Shunyi FAN
;
Yimei LI
;
Peng XI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Neuropathic pain;
Blood lipid;
Risk factor
- From:
Chinese Journal of Diabetes
2015;(5):456-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the related risk factors for neuropathic pain in diabetic rats.Methods Female Wistar rats of clean grade were divided into three groups :Non diabetic standard diet (NdStd) group (n=10) ,diabetic high fat diet and pain (DbHFP) group (n=10) ,and diabetic high fat diet and no pain (DbHFNP) group (n=10).Body weight ,blood glucose ,TG ,TC ,HDL‐C ,LDL‐C and 50%pain threshold were measured regularly to assess the relationship between blood lipids and pain. Results Non‐conditional logistic regression analysis showed that pain threshold was negatively correlated with TG , LDL‐C and blood glucose(P<0.05) ,and positively correlated with HDL‐C (P<0.05). And there was no association between TC and body weight (P> 0.05). Conclusion Pain threshold of diabetic rats was negatively correlated with TG ,LDL‐C and blood glucose ,and positively correlated with HDL‐C.
