Advance on the relationship between HIF-1α and angiogenesis deficiency in diabetes

VernacularTitle:缺氧诱导因子-1α与糖尿病血管新生的研究进展
Author: Ligen AI ; Fang LIU
Publication Type:Journal Article
Keywords: Hypoxia inducible factor-1α(HIF-1α); Diabetes mellitus,type 2; Angiogenesis; microRNA
From: Chinese Journal of Diabetes 2015;(5):470-474
CountryChina
Language:Chinese
Abstract: Hypoxia induced‐factor 1α(HIF‐1α) is a critical transcription factor involved in oxygen homeostasis which regulates a variety of cellular adaptive responses to hypoxia ,including angiogenesis , metabolism ,and apoptosis .In obesity ,adipose tissue dysfunction coupled with insulin resistance results in local hypoxia and angiogenesis disorders .Similarly ,type 2 diabetes (T2DM ) may present with chronic hypoxia ,inhibition of HIF‐1αproduction ,down‐regulation of angiogenesis factors ,and eventually cause a variety of vascular complications .Meanwhile ,the abnormal expression of microRNAs could affect the expression and function of HIF‐1α.HIF‐1α plays a very important role in angiogenesis ,wound healing , and so on .HIF‐1αhas been shown to improve angiogenesis by binding to a hypoxia‐response element and to regulate the expression of vascular endothelial growth factor (VEGF) .This review aims to summarize the advance on HIF‐1αand its impact on angiogenesis in diabetes .