Development of biocompatible dressing material made of collagen and amniotic membrane and wound healing experiment in rat.
- Author:
Kang Min AHN
1
;
Ji Ho LEE
;
Ui Lyong LEE
;
Jong Ho LEE
;
Jong Won LEE
;
Sung Po KIM
;
Eun Kyung YANG
;
Ki Ho KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Medicine, Ulsan University, Korea.
- Publication Type:Original Article
- Keywords:
Amniotic membrane;
Biocompatible dressing;
EGF;
EGF-R;
Wound healing
- MeSH:
Amnion*;
Animals;
Bandages*;
Biological Dressings;
Collagen*;
Epidermal Growth Factor;
Leukocytes;
Microvessels;
Neutrophil Infiltration;
Rats*;
Skin;
Wound Healing*;
Wounds and Injuries*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2006;32(3):189-199
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
<0.05). 4. Histologic examination revealed that AM protected leukocyte infiltration and epithelial migration was nearly completed at 4 weeks. Terudermis(R) group showed mild neutrophil infiltration until 2 weeks and completion of epithelization at 4 weeks. Control group showed massive leukocyte infiltration until 4 weeks. 5. Microvessels were increased sharply at 1 week and control group at 1 and 4 week showed significant differences with Terudermis(R) group of same interval(p<0.05) but no differences were found with AM group(p<0.05). CONCLUSION: EGF and EGF-R were well preserved in freeze-dried AM. AM attached to collagen acted as excellent biologic dressing which had similar effect with Terudermis(R). AM showed anti-inflammatory action and healing was completed at 4 weeks after full-thickness skin defect.
