Relationship between HBV DNA level, expression of PD-1 on CTL and liver functions in patients with hepatitis B virus cirrhosis
10.3969/j.issn.1006-5725.2015.07.010
- VernacularTitle:乙肝肝硬化患者HBV DNA水平与细胞毒性T淋巴细胞表面程序性死亡受体－1表达及肝功能的关系
- Author:
Dong WANG
;
Xibing GU
;
Yinfang ZHU
;
Yaping DAI
;
Qin TANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Hepatitis B cirrhosis;
HBV DNA;
CTL;
PD-1;
Liver functions
- From:
The Journal of Practical Medicine
2015;(7):1072-1075
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum HBV DNA level , expression of PD-1 on CTL and liver functions in patients with hepatitis B virus cirrhosis. Methods 109 HBV hepatic cirrhosis patients with , HBV DNA positive , HBeAg positive and HLA-A2 positive were divided into two groups according to their HBV DNA levels,52 cases in group A, HBV DNA 2-4 log10 copies/mL, 57cases in group B, HBV DNA 5-7 log10 copies/mL , differences of HBV specific CTL surface PD-1 expressions , HBV specific CTL levels and liver functions were compared between two groups. Results HBV specific CTL surface PD-1 expressions of group A were lower than that of group B (t = 11.101, P < 0.01), HBV specific CTL levels of group A were higher than that of group B (t = 24.424, P < 0.01), ALT of group A were lower than that of group B (t = 2.652, P < 0.01), ALB of group A were higher than that of group B (t = 2.347, P < 0.05). Child-pugh rating, grade C of group A was lower than that of group B (χ2= 4.262,P < 0.05). Conclusions HBV specific CTL surface PD-1 expression levels were higher in those hepatic cirrhosis patients with , high level of serum HBV DNA, and HBV specific CTL levels were lower, liver functions damage were much serious. So, lower HBV DNA levels , lower HBV specific CTL surface PD-1 expression levels and higher HBV specific CTL levels can product relatively good effect of anti-viral treatment.
