Expressions and clinical significance of STAT3 and HIF-1α in esophageal squamous cell carcinoma
10.3969/j.issn.1006-5725.2015.07.021
- VernacularTitle:STAT3和HIF-1α在食管癌中的表达及临床意义
- Author:
Shuoguo LI
;
Jun YAO
;
Shegan GAO
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
STAT3;
HIF-1α;
IHC
- From:
The Journal of Practical Medicine
2015;(7):1111-1113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of STAT3 and HIF-1α in esophageal squamous cell carcinoma (ESCC) and its relationships with clinical pathological characteristics and prognosis. Methods The expressions of STAT3 and HIF-1α protein were examined via immunohistochemistry in 50 cases of ESCC and normal esophageal mucosa tissue. Results In the immunohistochemistry of 50 ESCC , the positive expression rates of STAT3 and HIF-1α were 70% and 58%, respectively , significantly higher than those at the adjacent normal mucosa (P < 0.05). The expression of STAT3 in ESCC patients was significantly related to the lymph node metastasis, depth of invasion and TNM stage. The 30-month survival rates were positively correlated with the positive expression of STAT3 (P < 0.05). The expression of HIF-1α in ESCC patients was significantly related to the degree of differentiation and lymph node metastasis. The patients with HIF-1α negative had a higher cumulative survival rate than those with HIF-1α positive (P < 0.05), but the difference was not significant. STAT3 and HIF-1α were positively correlation with statistical significance (r = 0.362,P < 0.05). Conclusion STAT3 and HIF-1α are frequently expressed in ESCC. High expressions of STAT3 and HIF-1αmay contribute to the poor prognosis of human esophageal squamous cell carcinoma.
