Serum vitamin D levels in patients with systemic lupus erythematosus and their relationship with disease activity

VernacularTitle:系统性红斑狼疮患者外周血维生素D水平及其临床意义
Author: Qinyan LU ; Xiaoyan CAI ; Xiaojun LIN ; Chun TANG ; Jinhua YE ; Weinian LI ; Zhixiang HE ; Xinying LI ; Rongwei ZHANG
Publication Type:Journal Article
Keywords: Systemic lupus erythematosus; 25-OH-D; electrochemiluminescence
From: The Journal of Practical Medicine 2015;(7):1123-1125
CountryChina
Language:Chinese
Abstract: Objective To detect the serum 25- OH-D levels in patients with systemic lupus erythematosus (SLE) and investigate the function of vitamin D in the pathogenesis of SLE. Methods Eighty SLE patients including 40 healthy donors and 40 RA (rheumatoid arthritis) patients were enrolled in this study. Serum 25-OH-D levels were detected with ECL method. Results (1)Serum 25-OH-D levels in patients with active SLE were lower than those with inactive SLE patients and healthy controls. (2)Serum 25-OH-D levels were negatively correlated with SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) scores (r = -0.45,P < 0.01) and 24-hours urinary protein excretion (r = -0.32,P < 0.05). Conclusion Serum 25-OH-D levels in SLE patients decrease and have close relationship with disease activity and renal lesions.