Correlation between lipoprotein(a) and left main coronary artery disease in patients with acute coronary syndrome

VernacularTitle:脂蛋白（a）与急性冠脉综合征患者冠脉左主干病变的相关性
Author: Dongli SHANG ; Jianhua LIU
Publication Type:Journal Article
Keywords: Acute coronary syndrome; Lipoprotein (a); Left main coronary artery; Coronary artery disease
From: The Journal of Practical Medicine 2015;(7):1132-1134
CountryChina
Language:Chinese
Abstract: Objectives To explore the correlation between lipoprotein (a) and left main coronary artery ( LMCA) disease in patients with acute coronary syndrome (ACS). Methods A total of 264 ACS patients managed with coronary angiography (CAG) from June 2012 to December 2013 were included in the study and then they were divided into 2 groups (high-Lp(a) (> or = 300 mg/L) group (n = 93) and low-Lp(a) (< 300 mg/L)group(n = 171). The clinical data were studied and compared between the two groups. Binary unconditional logistic regression analysis was used to select the risk factors of LMCA disease. Results The percentages of multiple branch lesion (43.0% vs. 25.1%) and LMCA disease (17.2% vs. 8.2%)were higher in the high-Lp(a) group as compared with the low-Lp(a) group (P<0.05). Logistic regression analysis showed Lp(a) was independent factor of LMCA disease. Conclusions In ACS patients the elevated Lp(a) levels are associated with the severity of coronary disease and Lp(a) is an independent factor of LMCA disease.