The role of tumor-associated macrophages on microvessel density after neoadjuvant chemotherapy in tongue cancer.
- Author:
Bong Wook PARK
1
;
In Kyo CHUNG
;
Jong Ryoul KIM
;
Uk Kyu KIM
;
Bong Soo PARK
;
Gyoo Cheon KIM
;
June Ho BYUN
Author Information
1. Department of Dentistry, College of Medicine and Institute of Health Science, Research Institute of Life Science, Gyeongsang National University, Korea. surbyun@nongae.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
Neoadjuvant chemotherapy;
Vascular endothelial growth factor (VEGF);
Microvessel density;
Tumor-associated macrophage
- MeSH:
Drug Therapy*;
Humans;
Macrophages*;
Microvessels*;
Tongue Neoplasms*;
Tongue*;
Vascular Endothelial Growth Factor A
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2006;32(3):209-215
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
r cells, and the efficacy of drug delivery can be high in richly vascularized tumors. So, this study was conducted to evaluate the effect of neoadjuvant chemotherapy on microvessel density from 11 patients with tongue cancers. Our results showed that neoadjuvant chemotherapy was seemed to decrease VEGF expression in tumor cells, however, it did not significantly alter VEGF expression in tumor-associated macrophages. Also, Neoadjuvant chemotherapy had little effect on the microvessel density using CD34, and tumor-associated macrophage level using CD68. Thus, tumorassociated macrophages seem to be the key factor associated with the maintenance of microvessel density after neoadjuvant chemotherapy in tongue cancer.
