The expression of FGF-5 and FGF-7 in the cyclosporin a-induced gingival hyperplasia.
- Author:
Mi Hyang JEONG
1
;
Seong Gon KIM
;
Kyoung In YUN
;
Dong Seok NAHM
Author Information
1. Department of Orthodontics, College of Dentistry, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Cyclosporin-A;
Gingival hyperplasia;
FGF-5;
FGF-7
- MeSH:
Collagen;
Connective Tissue;
Cyclosporine*;
Fibroblasts;
Gingival Hyperplasia*;
Humans;
Immunohistochemistry;
In Situ Hybridization;
Mast Cells;
Organ Transplantation;
RNA, Messenger;
Transplants
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2006;32(3):216-221
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cyclosporin A-induced gingival hyperplasia is frequently found in the patients who have been received an immunosuppressant for the organ transplantation. However, its exact mechanism is still unknown. The expression of FGF-5 and FGF-7 were studied in cyclosporine A-induced gingival hyperplasia (CGH) and inflammatory gingival hyperplasia (IGH). Immunohistochemistry and in situ hybridization were used for localization of protein and mRNA. The expression of FGF-5 and FGF-7 was different from CGH and IGH. FGF-5 and FGF-7 was strongly expressed in fibroblast in CGH (P<0.005 and P<0.05, respectively). FGF-5 mRNA was localized in the middle portion of connective tissue. FGF-7 mRNA was also identified in fibroblasts and mast cells. In conclusion, FGF-5 and FGF-7 were produced excessively by fibroblasts in CGH. Considering their known functions, their expression in CGH is important for production of collagen and proliferation of fibroblasts.
