Effects of Shuanghuang Xiaocuo Pills on Contents of IL-8 and TNF-αin Rabbit Acne Models

VernacularTitle:双黄消痤丸对痤疮模型兔血清白细胞介素-8和肿瘤坏死因子-α含量的影响
Author: Lianwei KONG ; Qiyong GAO ; Lin MA ; Qian LI ; Hongli ZHANG ; Ran LU
Publication Type:Journal Article
Keywords: Shuanghuang Xiaocuo Pills; acne; IL-8; TNF-α; rabbits
From: Chinese Journal of Information on Traditional Chinese Medicine 2015;(6):72-74
CountryChina
Language:Chinese
Abstract: Objective To study action mechanism of Shuanghuang Xiaocuo Pills for treatment of rabbit ear acne models. Methods Totally 48 male Japanese white rabbits were divided into blank group, model group, positive medicine group, and Shuanghuang Xiaocuo Pills low, medium, and high dose groups through random number table method. Except for blank group, other groups established rabbit ear acne models. After the models were established, these groups received gavage with relevant medicine, once a day, for 14 days. Then all the rabbit models were under blood sampling. Radioimmunoassay was used to detect contents of IL-8 and TNF-α in serum. Results Compared with blank group, the contents of IL-8 and TNF-αincreased significantly in the model group (P<0.01). Compared with model group, except for Shuanghuang Xiaocuo Pills low dose group, the contents of IL-8 and TNF-αdecreased significantly in other treatment groups (P<0.01). Conclusion Shuanghuang Xiaozuo Pills can treat acne by reducing the contents of IL-8 and TNF-αin serum.