Progress of mathematical modeling for trandermal drug absorption
10.3969/j.issn.1001-1978.2015.05.002
- VernacularTitle:药物经皮吸收数学模型研究进展
- Author:
Xingyao HE
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
percutaneous absorption;
transdermal absorption;
prediction of percutaneous absorption;
mathematical model;
per-meability coefficient;
transdermal drug delivery;
percutaneous transport
- From:
Chinese Pharmacological Bulletin
2015;(5):596-600
- CountryChina
- Language:Chinese
-
Abstract:
Transdermal drug delivery is an administration route which can avoid the first-pass effect,maintain steady plasma concentrations and enhance bioavailability. Drug transporting through the skin by passage through the stratum corneum leads to the viable epidermis and the dermis.With the development of the computer technology,many mathematical models for predic-ting the absorption of drugs have been built according to physical and chemical properties of drugs and physiological characteristics of each skin layer.This article presented provides a summary of the progress of mathematical models for predicting percutaneous absorption of drugs.
