Research progress on factor XI as a novel target for antithrombotic therapy
10.3969/j.issn.1001-1978.2015.05.007
- VernacularTitle:凝血因子XI作为抗栓防治新靶点的研究进展
- Author:
Yahui CHEN
;
Dong LIU
;
Lifei PENG
- Publication Type:Journal Article
- Keywords:
coagulation factor XI;
thromboembolic disease;
an-tithrombotic drugs;
bleeding;
monoclonal antibody;
antisense ol-igonucleotides;
polypeptide
- From:
Chinese Pharmacological Bulletin
2015;(5):619-622
- CountryChina
- Language:Chinese
-
Abstract:
Thromboembolic diseases are major health problems worldwide,and remain the leading cause of mortality and disabil-ity at present.Bleeding is the most important complication of an-tithrombotic therapy for thromboembolism,therefore research and development of new antithrombotic drugs with lowered bleeding risk is a significant medical need.The data that elevated plasma levels of FXI are associated with thromboembolic diseases,se-vere FXI deficiency reduced incidence of DVT and ischemic stroke,and FXI deficiency or inhibition in animals shows protec-tive effects against thrombus formation supporting FXI as a novel antithrombotic target with lowered bleeding risk.This paper re-views the progress on FXI as a novel antithrombotic target and the inhibitors target FXI.
