Effects of ginkgo flavone on the expression of TLR4 and NF-κB in the liver of mice with nonalcoholic fatty liver disease
10.3969/j.issn.1006-5725.2015.07.016
- VernacularTitle:银杏黄酮对非酒精性脂肪肝小鼠肝脏Toll样受体－4和核因子－κB表达的影响
- Author:
Jihong BAI
;
Zhiqing LIANG
;
Rihong ZHAO
;
Yanhua LIU
;
Qiuxiang LIN
;
Xue ZHAO
- Publication Type:Journal Article
- Keywords:
Ginkgo flavone;
Non-alcoholic fatty liver disease;
Toll-like receptor 4;
Nuclear factor-κB;
Mice
- From:
The Journal of Practical Medicine
2015;(7):1091-1095
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ginkgo flavone on the expression of NF-κB and TLR4 in the liver of mice with nonalcoholic fatty liver disease (NAFLD). Methods 120 KM mice were randomly divided into the control group, model group, as well as high, medium and low dosage of ginkgo flavone groups. The animal model of NAFLD in mice was constructed with high fat diet. The pathological changes of liver, liver index , the serum TNF-α, IL-6 , TG , NF-κB and TLR4 in hepatic tissue was observed after 8 weeks of administration. Results Compared with the model group, the level of liver index, serum TG, TNF-α, IL-6 and the expression of NF-κBp65 in the ginkgo flavone groups dramatically decreased 8 weeks after the administration. And the hepatic steatosis was milder. There was no statistical differences in the expression of TLR4 between the ginkgo flavone groups and the control group (P > 0.05). Conclusions These results suggested the closely relationship between TLR4/NF-κB inflammatory pathway and NAFLD. Ginkgo flavone had the therapeutical effects on NAFLD by anti-inflammatory and lipid-lowering action, but no effect was observed on the expression of TLR4 in hepatic tissue.
