The level of advanced oxidation protein products in serum is associated with dialysate glucose exposure dose in patients undergoing non-diabetic maintenance peritoneal dialysis
10.3969/j.issn.1006-5725.2015.07.022
- VernacularTitle:非糖尿病腹膜透析患者血清晚期氧化蛋白产物水平与透析液葡萄糖暴露程度的相关性
- Author:
Xiaobin YANG
;
Dongfeng GUO
;
Weiwei NI
;
Jianping JIANG
- Publication Type:Journal Article
- Keywords:
Advanced oxidation protein products;
Maintenance peritoneal dialysis;
Glucose exposure dose
- From:
The Journal of Practical Medicine
2015;(7):1114-1116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the level of advanced oxidation protein products (AOPP) in serum and the dialysate glucose exposure dose in patients undergoing non-diabetic maintenance peritoneal dialysis (PD). Methods In this cross-sectional study, the levels of serum AOPP were measured in 192 non-diabetic PD patients. Based on the exposure dose of dialysate glucose , PD patients were assigned into the high-dose exposure and low-dose exposure groups. Serum C-reactive protein levels were also measured and the rates of cardio-vascular disease (CVD) were recorded in both groups. Results The levels of serum AOPP were higher in the high-dose exposure group, as compared with the low-dose exposure group [(78.7 ± 15.6) mmol/L vs. (71.7 ± 14.8) mmol/L, P = 0.003]. The serum C-reactive protein levels [4.6 (3.0-11.4) mg/L vs. 3.0 (2.2-5.3) mg/L, P < 0.001] and the rates of CVD (53.6% vs. 35.8%, P = 0.014) were also higher in the high-dose exposure group. After multivariate adjustment ,the level of serum AOPP was independently associated with dialysate glucose exposure dose (β = 0.157, P = 0.031) and duration of PD (β = 0.164, P =0.043). Conclusion The serum AOPP levels are associated with the dialysate glucose exposure doses in non-diabetic PD patients. Minimizing the glucose load might reduce the risk of developing CVD.
