Clinical Study on Compound Sophora Flavescentis Radix (Kushen) Injection Combined with Gamma Knife for Treatment of Locally Advanced Pancreatic Carcinoma
10.3969/j.issn.1005-5304.2015.06.007
- VernacularTitle:复方苦参注射液联合伽玛刀治疗局部晚期胰腺癌临床研究
- Author:
Lei WANG
;
Lingzhao LI
;
Xiaofang WANG
;
Guoyong SHAN
;
Rui LIU
;
Song ZHANG
;
Xiaodong WU
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
Compound Sophorae Flavescentis Radix (Kushen) Injection;
gamma knife
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(6):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of Compound Sophorae Flavescentis Radix (Kushen) Injection combined with gamma knife for treatment of locally advanced pancreatic carcinoma. Methods Totally 65 patients of locally advanced pancreatic cancer were randomly divided into two groups:32 cases of simple gamma knife group (group A), 33 cases of Compound Kushen Injection combined with gamma knife treatment (group B). Patients received enhancement computed tomography scanning and CA199 review at 1, 3, 6, 9, 12 months after treatment, and once every six months, a total of 36 months of follow-up. Short-term and long-term efficacy was observed after treatment, and survival curve analysis was carried out. Results Clinical benefit response was 53.13% in group A and 84.85% in group B (P=0.006);median survival time of two groups was 11.00 months in group A and 23.00 months in group B;the average survival time in group A was 16.37 months, and 22.28 months in group B (P=0.017). In the two groups, treatment of the 65 patients was completed smoothly as planned, and no one had serious complications, such as pancreatic leakage, skin burns, viscera perforation and radioactive enteritis. Conclusion Compound Kushen Injection combined with gamma knife can treat locally advanced pancreatic carcinoma safely and efficiently, which can improve patients’ life quality, especially in cancer pain control.
