Determination of Pharmacokinetic Parameters of P-methoxybenzyl Alcohol from Gastrodiae Rhizoma in Plasma of Rats by HPLC
10.3969/j.issn.1005-5304.2015.06.028
- VernacularTitle:HPLC测定天麻成分对甲氧基苄醇在大鼠血液中的药代动力学参数
- Author:
Xiaohua DUAN
;
Weili WANG
;
Shuang WU
;
Hanwen YAN
;
Lisong LIU
;
Qing LIN
- Publication Type:Journal Article
- Keywords:
HPLC;
P-methoxybenzyl alcohol;
pharmacokinetics;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(6):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the pharmacokinetic parameters of P-methoxybenzyl alcohol from Gastrodiae Rhizoma in plasma of rats by HPLC. Methods Gavage and intravenous injection were employed for administration. HPLC was used to determine the concentrations of P-methoxybenzyl alcohol from Gastrodiae Rhizoma in plasma of rats in different time points. The pharmacokinetic parameters were computed by DAS3.0. Results The linear range of P-methoxybenzyl alcohol in plasma was 0.63-321.17 μg/mL, r 2=0.994 5. Intra-day accuracy, inter-day accuracy, absolute recovery and stability were in specified range. Conclusion The method is simple and accurate for the determination of the pharmacokinetic parameters of P-methoxybenzyl alcohol from Gastrodiae Rhizoma in plasma of rats.
