Experimental Study of Prevention and Therapeutic Effect of Jinyebaidu Granules on Cytomegalovirus Infection During Mid-pregnancy
10.3870/yydb.2015.05.005
- VernacularTitle:金叶败毒颗粒防治妊娠中期巨细胞病毒宫内感染的实验研究
- Author:
Wei LI
;
Jinwen XIONG
;
Juanjuan CHEN
;
Tao LIU
;
Juan XIAO
;
Jing LIU
;
Yanli ZHANG
;
Yun FENG
;
Xue ZENG
;
Suhua CHEN
- Publication Type:Journal Article
- Keywords:
Jingyebaidu granules;
Cytomegalovirus;
Infection,intrauterine
- From:
Herald of Medicine
2015;(5):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Jingyebaidu granules on treating cytomegalovirus ( CMV) infection during mid-pregnancy. Methods The sexually mature guinea pigs with no CMV infection history served as the subjects. Put the male and female ones in the same cages. Then the female ones were randomly divided into three groups during mid-pregnancy. Model control group:15 guinea pigs which were inoculated 1 mL suspension of GPCMV intraperitoneally. Jingyebaidu Medicine group:15 guinea pigs which were treated with Jingyebaidu(3. 09 mL·kg-1 ) through stomach perfusion after inoculation for 14 days. Normal control group:15 normal mid-pregnant guinea pigs. Viremia rates were examined 7 days after infection. All animals were sacrificed 20 days after infection. The placenta infection rate, pup infection rate, still-born rate were examined. Results Compared with the normal controls, the still-born rate was increased in model control group(8. 33% vs 34. 55%, P<0. 05). In comparison to the model control group, the GPCMV maternal infection rate(86. 67% vs 33. 33%), placenta infection rate (91. 67% vs 61. 22%), pup infection rate(90. 91% vs 48. 28%), still-born rate(34. 55% vs 15. 52%) were significantly decreased in the Jinyebaidu group (all P<0. 05). Conclusion Jinyebaidu granules could reduce maternal infection,pup loss, and placenta infection caused by CMV inoculation during mid-pregnancy.
