Eliminating Phlegm and Stopping Cough by Kujyukekuan Mixtures and Its Acute Toxicity
10.3870/yydb.2015.05.009
- VernacularTitle:苦橘咳喘合剂的止咳化痰作用与急性毒性
- Author:
Huijin DENG
;
Xia LI
;
Jinmei ZHANG
;
Yongxin YU
;
Xin ZOU
;
Lijun XU
- Publication Type:Journal Article
- Keywords:
Kujyukekuan mixtures;
Relieving cough effects;
Reducing phlegm effects;
Toxicity,acute
- From:
Herald of Medicine
2015;(5):603-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relieving cough and reducing phlegm effects and acute toxicity of the Kujyukekuan mixtures. Methods The method used in our study is a cough model induced by the ammonia water , the phenol red test in mice, the mouse pinna swelling model induced by xylene and the maximum tolerant dose experiment. Results In antitussive experiments, R value of Kujyukekuan mixtures at low, medium and high dose of was 112. 26%, 143. 29%, 162. 07%, respectively regarding as ineffective, effective and marked effective;Kujyukekuan mixtures at medium and high doses increased the excretion of phenolsulfonphthalein in the trachea of mice (compared with the normal control group, P<0. 05 or P<0. 01),the results showed good concentration-response relationship;Kujyukekuan mixtures at low, medium and high dose significantly reduced mouse auricle swelling caused by xylene (compared with normal control group, P<0. 01), the results presented a good concentration-response relationship;the MTD of Kujyukekuan mixture was 326. 76 g·kg-1. Conclusion Kujyukekuan mixtures at medium and high doses exert significant eliminating cough and phlegm effects and strong anti-inflammatory property, and has a good security.
