Study of the Intestinal Absorption Mechanism of Galangin in Rats
10.3870/yydb.2015.05.012
- VernacularTitle:高良姜素在大鼠肠道的吸收机制
- Author:
Junlin HU
;
Tao YANG
;
Kaiyong HE
- Publication Type:Journal Article
- Keywords:
Galangin;
Intestinal absorption;
Single-pass intestinal perfusion;
Chromatography,high performance liquid
- From:
Herald of Medicine
2015;(5):612-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the absorption characteristics of galangin in various intestinal segments. Methods Single-pass intestinal perfusion was employed in rats, and the mass quality was used to correct the volume;Galangin in rat intestinal perfusion was determined by HPLC to investigate the effects of intestinal segments, drug concentration and P-glycoprotein ( P-gp) inhibitor on drug’ s absorption. Results Galangin could be absorbed in the whole intestine, and its Ka values in the segments of duodenum, jejunum, ileum and colon were (5. 12±1. 14)í10-2,(2. 23±1. 02)í10-2,(4. 61± 0. 75)í 10-2 and(2. 68 ± 0. 70)í10-2 ·min-1 ,respectively. Meanwhile, the values of the Ka in the segment of ileum were not affected by the drug concentration and P-gp inhibitor. Conclusion The galangin is well absorbed in rats intestinal segments. The absorption procedure is mainly controlled by passive diffusion but unaffected by P-gp efflux protein.
