Optimization of Preparation for Venlafaxine Hydrochloride W/O Emulsion by Central Composite Design-Response Surface Methodology

VernacularTitle:星点设计效应面法优化盐酸文拉法辛油包水乳剂处方
Author: Keke WANG ; Lixin YI ; Mingyan JIANG
Publication Type:Journal Article
Keywords: Venlafaxine,hydrochloride; Central composite design; Response surface; W/O emulsion; Emulsification-ultrasound divergence method
From: Herald of Medicine 2015;(5):644-648
CountryChina
Language:Chinese
Abstract: Objective To optimize the formulations of venlafaxine hydrochloride ( VH ) emulsions by using central composite design-response surface methodology. Methods The effect of amounts of Arlacel P135, VH, PEG-400, and NaCl on the emulsion viscosity, centrifugation breakage, and mean diameter was systemically investigated, respectively. The desirable formulation that combining these three response variables was constructed. Linear equations and a second-order polynomial equation were fitted to the data, and the outcome equation was used to predict the responses in the optimal region. Results There was a quantitative relationship between 4 factors and 3 evaluation indexes and evaluation the “desirability” . The optimal formulation of the VH emulsion were as follows:taking 0. 48 g of Arlacel P135, 0. 40 g of VH, 0. 26 g of PEG-400, and 0. 025 g of NaCl. The experimental values of the response variables were highly closed to the predict values. Conclusion The model presents good prediction and can be used to optimize the preparation of VH emulsion, which obtaining stable W/O emulsion.