Expression of CD44+/C-myc+cancer stem cells and its relationship with the prognosis of patients in colorectal tumors
10.3969/j.issn.2095-4344.2015.14.006
- VernacularTitle:CD44+/C-myc+癌干细胞在结直肠肿瘤中表达及与预后的关系
- Author:
Faku MA
;
Huan WANG
;
Bin LIU
;
Yanli YANG
;
Qinjun SU
;
Zhen QIAN
;
Liang DONG
- Publication Type:Journal Article
- Keywords:
Colorectal Neoplasms;
Neoplastic Stem Cells;
Genes,myc;
Cell Adhesion Molecules
- From:
Chinese Journal of Tissue Engineering Research
2015;(14):2161-2166
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Tumor recurrence results from the incomplete removal of cancer stem cel s with self-renewal characteristics, and then how to label and eliminate cancer stem cel s becomes the key to cancer treatment. OBJECTIVE:To observe the morphology,distribution and number of CD44+/C-myc+METHODS:Pathological tissues from 150 patients with colorectal cancer were taken to prepare tissue microarray, in order to observe and count CD44 cel s in colorectal cancer, and to explore the relationship between the expression and postoperative metastasis.+/C-myc+cel s by using immunohistochemical double staining. Patients were fol owed up through mobile phones , letters , and so on, and the relationship between the expression of CD44+/C-myc+cel s and postoperative metastasis were statistical y recorded.RESULTS AND CONCLUSION:There was no CD44+/C-myc+cel s in normal tissue and little in adenoma. A smal number of CD44+/C-myc+cel s distributed as dots or focal lesions in adenocarcinoma. The number of CD44+/C-myc+cel s was related to the degree of adenocarcinoma differentiation, depth of invasion, and lymph node metastasis (P<0.05). The univariate analysis showed that the overal survival rate and progression-free survival rate were associated with the number of CD44+/C-myc+cel s, lymph node metastasis and Ducks staging in adenocarcinoma (P<0.05). The multivariate analysis showed that the overal survival rate was related to CD44+/C-myc+cel amount and the progression-free survival rate was related to CD44+/C-myc+cel amount and the Ducks staging. Therefore, CD44+/C-myc+cel s are probably cancer stem cel s, and Ducks staging and CD44+/C-myc+cel amount are important prognostic factors for colorectal cancer.
