Relationship between intestinal dysbacteriosis and circadian clock disturbance
10.3969/j.issn.1000-4718.2015.05.033
- VernacularTitle:肠道菌群失调与生物钟紊乱的相关性
- Author:
Wenya HUANG
;
Fuer LU
;
Hui DONG
- Publication Type:Journal Article
- Keywords:
Intestinal flora;
Dysbacteriosis;
Circadian clocks
- From:
Chinese Journal of Pathophysiology
2015;(5):950-955
- CountryChina
- Language:Chinese
-
Abstract:
The human gut harbours a certain quantity and variety of microbes called intestinal flora, which is in a state of balance under normal circumstances, and dysbacteriosis occurs when the balance of the intestinal flora is dis-turbed by the host and the changes of the external environment.Circadian clock is the biological regulation system to adapt to natural circadian rhythm, including central clock and peripheral clock.Circadian clock disturbance, particularly rotating shift-workers with irregular light-night schedules, is associated with an increased risk of immune-related diseases.The de-velopment of these diseases is closely related to intestinal dysbacteriosis.Therefore, the correlation between intestinal dys-bacteriosis and circadian clock disturbance has attracted much attention.This review aims to explore the pathophysiological basis of the development in some immune-related diseases based on the latest scientific findings about the relationship be-tween intestinal microbial flora and circadian clock.
