Function of long noncoding RNA in energy metabolism and related diseases
10.3969/j.issn.1000-4718.2015.05.034
- VernacularTitle:长链非编码 RNA对能量代谢和相关疾病发生发展的作用
- Author:
Can RONG
;
Yun HU
- Publication Type:Journal Article
- Keywords:
Long noncoding RNA;
Metabolic disease
- From:
Chinese Journal of Pathophysiology
2015;(5):956-960
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNA ( lncRNA) is a functional RNA molecule longer than 200 nucleotides.They are involved in epigenetic, transcriptional and post-transcriptional modifications, playing an important role in gene expres-sion, chromatin remodeling, histone modification, X chromosome inactivation, genomic imprinting, protein folding and ac-tivity as well as other important biological events.Some studies have proven that lncRNAs are involved in the development of metabolic diseases.The changes of their expression levels may be new diagnostic markers and therapeutic targets.
