Changes of plasma levels of soluble VEGFR2 and SOD in hypertensive patients and hypertensive diabetic patients
10.3969/j.issn.1000-4718.2015.05.005
- VernacularTitle:高血压和高血压合并糖尿病患者血浆可溶性 VEGFR2与 SOD 水平的变化
- Author:
Shujie YU
;
Bin ZHOU
;
Zhiming SONG
;
Yong LIU
;
Baoshun HAO
;
Min WANG
;
Zhen WU
;
Lin CHEN
;
Xiaoxian QIAN
;
Jieming ZHU
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor receptor 2;
Superoxide dismutase;
Diabetes mellitus;
Hyper-tension;
Angiogenesis
- From:
Chinese Journal of Pathophysiology
2015;(5):797-801
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the changes of plasma levels of soluble vascular endothelial growth factor receptor 2 ( sVEGFR2) and superoxide dismutase ( SOD) in hypertensive patients and hypertensive diabetic patients.METHODS:In this cross-sectional study, 88 cases were enrolled, which were divided into hypertensive group (n=31), hypertensive diabetic group ( n=31 ) and control group ( n=26 ) .Blood pressure was obtained from each participant with mercury sphygmomanometer.The levels of sVEGFR2 and SOD were measured by ELISA.Meanwhile, the levels of plasma glucose, glycosylated hemoglobin A1c ( GHbA1c) and lipid profile were detected.RESULTS:The levels of total cholesterol ( TC) and body mass index (BMI) were significantly higher in hypertensive group than those in control group (P<0.05).The levels of TC, low-density lipoprotein cholesterol ( LDL-C) , triglyceride ( TG) , BMI, waist circumference were significantly higher in hypertensive diabetic group than those in control group (P<0.05).The plasma levels of sVEGFR2 and SOD in both hypertensive diabetic group and hypertensive group were significantly decreased compared with control group ( P<0.05), while the mean plasma levels of sVEGFR2 and SOD in hypertensive diabetic group were significantly decreased compared to the hypertensive group ( P<0.05 ) .A significantly positive correlation between sVEGFR2 and SOD in the whole study population (P<0.05) was observed.CONCLUSION: The plasma level of sVEGFR2 is decreased in both hypertensive and hypertensive diabetic patients, and more significantly decreased in hypertensive diabetic patients.De-creased SOD level may be associated with to the reduction of sVEGFR2.
