Efficacy of Olanzapine Combined with Tropisetron, Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-induced Nausea and Vomiting
10.11969/j.issn.1673-548X.2015.05.040
- VernacularTitle:奥氮平联合托烷司琼、地塞米松预防高致吐风险药物化疗引起恶心、呕吐的疗效分析
- Author:
Xiaoxiao DING
;
Xinhua DING
- Publication Type:Journal Article
- Keywords:
Olanzapine;
Tropisetron;
Dexamethasone;
Chemotherapy-induced nausea and vomiting
- From:
Journal of Medical Research
2015;44(5):143-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and side effect of olanzapine combined with tropisetron, dexamethasone for the pre-vention of highly emetogenic chemotherapy-induced nausea and vomiting ( CINV) . Methods A total of 78 patients with highly emetogen-ic single day chemotherapy were randomly divided into two groups:trial group ( olanzapine combined with tropisetron, dexamethasone n=40) and control group (Tropisetron Combined with Dexamethasone n=38). The control of acute CINV, delayed CINV and adverse reac-tions were observed. Results The control rates of acute vomiting in trial group and control group were 87. 5% vs 81. 6%, 65. 0% vs 57. 9% in acute nausea, 75. 0% vs 52. 6% in delayed vomiting, 32. 5% vs 13. 2% in delayed nausea. The trial group was better than the control group in delayed vomiting and delayed nausea which there was difference between them (P < 0. 05). There was no statistical differ-ence between the two groups in the incidence of adverse reactions (P>0. 05). Conclusion Olanzapine combined with tropisetron, dexa-methasone for the prevention was significantly better than tropisetron combined with dexamethasone in the control of delayed CINV in pa-tients received highly emetogenic chemotherapy.
