Clinical Significance of HBV Molecular Genotypes and Quantitative Serology Detection in Patients with Chronic Hepatitis B
10.11969/j.issn.1673-548X.2015.05.045
- VernacularTitle:慢性乙型肝炎患者HBV基因表型与血清学测定的临床意义
- Author:
Lijiang GU
;
Jinsong BU
;
Jie CHEN
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Virus genotype;
Quantitative serological detection;
Disease outcomes
- From:
Journal of Medical Research
2015;44(5):160-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To characterize the molecular genotypes and quantitative serological biomarker, and to explore their clinical significance in patients with chronic hepatitis B ( CHB) . Methods A total of 210 CHB patients were enrolled and HBV DNA loading, HBV molecular genotypes, quantitative serological biomarker, and ALT were measured. Patients were grouped according to the natural phases of HBV infection:HBeAg (+) immune tolerance, immune clearance, HBeAg (-) low replicative and reactivation phase. The correlation was analyzed between molecular genotypes and serological biomarkers, HBsAg and other biomarkers. Results Subgenotypes B2 with high level of HBV DNA and C2 with middle level of HBV DNA were found to be most prevalent. The positive rates were 59. 0%(B2) and 25. 2%(C2). Patients genotype with B showing more potent viral activity. Subgenotype B2 was sinificantly corelated with HB-sAg, HbeAg, and ALT levels(P < 0. 01), but there was no statistical difference for subgenotype C2. There was statistical difference be-tween positive rates of subgenotypes(P>0. 05), but HBsAg level was found to be significantly correlated with HBV DNA, HBeAg, ALT levels during some phases of CHB. Conclusion Molecular genotyping and quantitative serological biomarkers detection might be helpful for earlier prediction of the long-term disease outcomes in patients with CHB.
