The solubility, permeability and their interaction of daidzin and daidzein
10.3760/cma.j.issn.1673-4246.2015.05.013
- VernacularTitle:大豆苷及大豆苷元溶解吸收特性差异比较及相互作用研究
- Author:
Honghuan DONG
;
Yanli PAN
;
Yang LIU
;
Lei ZHANG
;
Xiaoyun MA
;
Zhiqiang LUO
;
Liyuan YANG
;
Ruirui YANG
- Publication Type:Journal Article
- Keywords:
Daidzin;
Daidzein;
Solubility;
Permeability;
Interaction
- From:
International Journal of Traditional Chinese Medicine
2015;(5):439-442
- CountryChina
- Language:Chinese
-
Abstract:
Objective The alm of this study was to determine the solubility and permeability of daldzin and daldzein and the interaction of these two components.Methods With the method inChinese Pharmacopoeia and in situ single-pass intestinal perfusion model we tested the solubility and permeability of daldzin, daldzein and their interaction.Results In pH 7.4 K-R buffer the solubility of daldzin was 6 times than daldzein and both the solubility of these two components were enhanced when they were determined together. In small intestine of rat, the permeability of daldzein was 3 times than daldzin. Daldzin could enhance the permeability of daldzein but the daldzein manifested an opposite trend.Conclusion When compared to daldzin, daldzein owned a lower solubility but a better permeability. When used together, both the solubility and permeability of daldzein would be enhanced. The solubility of daldzin could be enhanced slightly but its permeability would be reduced.
