Transdermal Penetration Enhancement of Arginine Oligomer-chitosan on Tinidazole in vitro and in vivo
- VernacularTitle:寡聚精氨酸壳聚糖对替硝唑透皮吸收促进作用的体内外研究
- Author:
Liu PING
;
He WEN
;
Wang JING
;
Liu BEI
- Publication Type:Journal Article
- Keywords:
Arginine oligomer;
Chitosan;
Transdermal penetration enhancer;
Tinidazole
- From:
China Pharmacist
2015;(5):707-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the in vitro and in vivo transdermal enhancement of one kind of arginine oligomer-chitosan ( CS-R9). Methods: In vitro mouse skin as the barrier, Franz diffusion cells were used to study the transdermal property of tinidazole ( TNZ) solution in vitro enhanced by CS-R9 using TNZ solution as the negative control and TNZ solution with Azone as the positive control. The rats were randomly divided into three groups, TNZ solution group ( the negative group) , TNZ solution with Azone group (the positive group) and TNZ solution with CS-R9 group. At the predetermined time intervals, 0. 5 ml blood was withdrawn from the rats and TNZ concentration was detected by HPLC to evaluate the enhancement of CS-R9 on TNZ in vivo. Results:Compared with the negative group, CS-R9 had significant enhancement on TNZ trandermal penetration in vitro(P <0.05), and showed no significant difference with Azone (P>0. 05). The in vivo results showed CS-R9 exhibited similar transdermal enhancement on TNZ as Azone at the same concentration (P>0. 05), and CS-R9 had sustalned-release property. Conclusion: CS-R9 has promising transdermal en-hancement on TNZ, which is valuable to be studied further.
