Expression and significance of IL-10 and TGF-β1 in serum of patients with systemic lupus erythematosus
10.7644/j.issn.1674-9960.2015.04.010
- VernacularTitle:IL-10和TGF-β1在系统性红斑狼疮患者血清中的表达及意义
- Author:
Qiang ZHU
;
Minghua ZHU
;
Jun LUO
;
Hao WANG
;
Jingzhi HE
;
Hua LIU
;
Xuyan WANG
- Publication Type:Journal Article
- Keywords:
lupus erythematosus,systemic;
cytokines;
interleukin-10;
TGF-β1
- From:
Military Medical Sciences
2015;(4):276-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of IL-10 and TGF-β1 and their significance for patients with sys-temic lupus erythematosus( SLE) .Methods A total of 135 cases were available for the study including 63 cases in primary group(A), 40 cases in remission group(B) and 32 cases in healthy control group(C).ELISA method was used to deter-mine the concentrations of IL-10 and TGF-β1 in serum.Finally, the results of group A were analyzed on the basis of System-ic Lupus Erythematosus Disease Activity Index( SLEDAI) .Results The level of IL-10 in serum of group A was significant-ly higher than that of group B and group C.The level of IL-10 in serum of group B was significantly higher than that of group C(P<0.05).The level of IL-10 in group A had active correlation with SLEDAI.The level of TGF-β1 in serum of group A was significantly lower than that of group B and group C.There was no statistical difference between group B and group C(P>0.05).The level of TGF-β1 in serum of group A had negative correlation with SLEDAI.The cases in group A were divided into three subgroups by SLEDAI:21 cases in mild activities subgroup, 30 cases in moderate activities sub-group,and 12 cases in severe activities subgroup, the levels of IL-10 and TGF-β1 in the three subgroups were significantly different(P<0.05).Conclusions IL-10 and TGF-β1 are involved in activity and severity of SLE.
