Monocyte chemotactic protein 1-induced protein and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2015.03.015
- VernacularTitle:单核细胞趋化蛋白1诱导蛋白与脑缺血
- Author:
Shaofei HUANG
;
Xiaoxi LIU
;
Liang ZHOU
- Publication Type:Journal Article
- Keywords:
Brain Ischemia;
Chemokine CCL2;
Inflammation;
Cytokines;
Neovascularization,Physiologic;
Blood-Brain Barrier;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2015;(3):229-233
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia-induced inflammatory cascade reaction may aggravate nerve tissue damage and destroy blood-braln barrier, and angiogenesis after ischemia can improve nerve function. Inhibiting inflammatory response after stroke, promoting angiogenesis and protecting blood-braln may reduce nerve tissue damage and promote recovery of neurological function. Monocyte chemotactic protein 1-induced protein inhibits inflammatory signaling pathways through degradating proinflammatory cytokine mRNA. Its unique biological characteristics also suggest that it has the potential protective effect in cerebral ischemia. This article focuses on the roles of monocyte chemotactic protein 1-induced protein in cerebral ischemia.
