Discussion on Protective Effects of Histone Modiifcations for Myocardial Ischemia by Acupuncture
10.11842/wst.2015.04.013
- VernacularTitle:组蛋白修饰在针刺促缺血心肌保护中的作用探析
- Author:
Ning WANG
;
Shengfeng LU
;
Bingmei ZHU
- Publication Type:Journal Article
- Keywords:
Histone modification;
acetylation;
methylation;
acupuncture;
myocardial ischemia
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;17(4):829-835
- CountryChina
- Language:Chinese
-
Abstract:
Protective effects of acupuncture on myocardial ischemia in each stage have been confirmed increasingly, while there was no in-depth research in terms of histone modifications. Histone modification is an important part of epigenetics. It is also the focus of molecular biology and basic medical research. In this paper, the relationship of histone modifications and gene expression of heart was first explained. Then, the recent research progress of modified histones, which was the direct alteration of gene expression induced by histone modifications on the degree and prognosis of myocardial ischemic injury, was reviewed. This investigation introduced epigenetic regulation in the protection mechanism of myocardial ischemia by acupuncture. It provided new ideas and directions for the study of molecular mechanism of acupuncture efficacy.
