Effect of Acupuncture on HDAC2 Activity in Peripheral Blood of COPD Rats

VernacularTitle:中医针刺治疗对COPD模型大鼠外周血HDAC2活性的影响
Author: Jie ZHANG ; Yahong CAO ; Xiaobo ZHU ; Mingming ZHOU ; Xinhui ZHU ; Wei LIU
Publication Type:Journal Article
Keywords: Acupuncture; chronic obstructive pulmonary disease; HDAC2; inflammation
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;17(4):861-864
CountryChina
Language:Chinese
Abstract: This article was aimed to explore the effect of acupuncture on HDAC2 activity in peripheral blood of chronic obstructive pulmonary disease (COPD) rats. The COPD rat model was established by cigarette smoking. Acupuncture was given for 3 consecutive weeks. The lung ventilation of rat was detected by equipment. Peripheral blood of rat was taken after 3 weeks. The HDAC2 enzyme activity was detected by fluorescence technology. ELISA was used in the detection of IL-10, IL-8 and TNF-αexpression in peripheral blood. The results showed that after acupuncture treatment, the lung ventilation was obviously increased compared with the model group (P < 0.05). Meanwhile, the HDAC2 activity in the peripheral blood of rat was obviously increased (P < 0.05). However, the expression of inflammatory cytokines IL-10, IL-8 and TNF-α was obviously reduced (P < 0.05). It was concluded that acupuncture treatment had a good efficacy on COPD rat. It indicated that acupuncture treatment might regulate HDAC2 activity to reduce inflammation.