Optimization and Preliminary Evaluation the Formulation of Self-microemulsifying Drug Delivery System of Potassium Dehydroandrographolidi Succinas
10.11842/wst.2015.03.049
- VernacularTitle:穿琥宁自乳化给药系统处方筛选及评价
- Author:
Hao WANG
;
Mingquan CUI
;
Rongli YIN
;
Zhimin CI
;
Quanyi YU
- Publication Type:Journal Article
- Keywords:
Potassium dehydroandrographolidi succinas;
self-emulsifying;
ternary phase diagrams;
quality assessment
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;17(3):712-718
- CountryChina
- Language:Chinese
-
Abstract:
The self-microemulsion formulation of potassium dehydroandrographolidi succinas (PDS) has been optimized and the performance in vitro has been evaluated preliminary. Kinds of prescription accessories were screened by solubility based on the emulsifying result and efficiency, particle size of emulsions. The optimal formulation composition and compatibility proportion were determined by orthogonal design and pseudo-ternary phase diagrams. The appearance, particle size, Zeta potential and stability of this formulation were also investigated. The optimized prescription of PDS was 10% MCT, 40% Tween-20 and 50% glycerol. It can spontaneously form a transparent pale blue opalescent emulsion with emulsification time 31.27 s, particle size 37.1 nm, Zata potential -17.4 mV and good stability.
