Optimization Research on TCM Compound Prescription in Insomnia Treatment
10.11842/wst.2015.03.037
- VernacularTitle:治疗失眠中药小复方剂量优化研究
- Author:
Hong ZHANG
;
Yv GAN
;
Min QIAO
;
Guanghan WANG
;
Huizong ZHANG
;
Fei WANG
;
He CHEN
;
Yinglan FAN
;
Lei ZHAO
- Publication Type:Journal Article
- Keywords:
Insomnia;
uniform design;
comprehensive scoring method;
dose optimization;
pharmacodynamics;
toxicology
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;17(3):638-642
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to screen out a safe and effective traditional Chinese medicine (TCM) compound prescription in insomnia treatment, through the method of uniform design and comprehensive scoring method. It provided candidate drugs to further research and development of TCM new drug. U7(76) uniform design was used to divide groups. The test was given on sleep time prolonging effect of mice injected with pentobarbital sodium. The subliminal dosage of pentobarbital hypnosis was tested on mice injected with pentobarbital sodium. The acute toxicity (LD50) was tested on mice. Comprehensive scoring method was applied to evaluate the effect to determine the optimum dose. The results showed the optimized prescription was composed of Radix Sophorae Flavescentis and Schisandra chinensis. The optimum ratio was 1:3. It was concluded that the uniform design was applied in the experimental design with 3 factors and 6 levels. Comprehensive scoring method was used to evaluate the combined effect. The optimized prescription that put benefit and risk into consideration was composed of Radix Sophorae Flavescentis and Schisandra chinensis. The best ratio was 1:3, which can be further developed.
