Spectrum-Effect Relationship of Ethyl acetate Fraction in Ethanol Extract fromXiaoyaosan(XYE-E) for Antidepressant Effect Based on1H-NMR

VernacularTitle:基于1H-NMR指纹图谱研究逍遥散乙醇提取物的乙酸乙酯萃取物抗抑郁谱效关系
Author: Xiaofen ZHEN ; Lei CHEN ; Junsheng TIAN ; Xuemei QIN
Publication Type:Journal Article
Keywords: Ethyl acetate fraction in ethanol extract of Xiaoyaosan; 1H-NMR; relationship of fingerprint and efficacy; tail suspension test; forced swimming test
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;17(3):563-568
CountryChina
Language:Chinese
Abstract: Thearticle is aimed to find the correlation between bioactive components of XYE-E and the antidepressant efficacy, by analyzing the immovability time in tail suspension test (TST) and forced swimming test (FST). Using the method of gray relational analysis, correlation analysis and regression analysis, relating the peak area of each common peak of1H-NMR spectra with the immovability time in TST or FST, we found that there were total 14 chemical components identified in the1H-NMR spectrum of XYE-E. Among them, 8 compounds, including saikosaponin a, saikosaponin c, saikosaponin E, saikosaponin F, saikosaponin G, saikosaponin b2, atractylenolide I and atractylenolide II, had significant correlation with antidepressant efficacy.