Bisphosphonates combined with surgical treatment is better to inhibit bone resorption of long bones with fibrous dysplasia
10.3969/j.issn.2095-4344.2015.15.006
- VernacularTitle:双膦酸盐对四肢长骨纤维结构不良骨吸收的抑制：配合外科手术效果更好
- Author:
Hongsheng YANG
;
Xiaohu YAN
;
Yugang LI
;
Zongrui CAO
;
Zhanli LIU
;
Xiaoping XU
;
Shan CHANG
- Publication Type:Journal Article
- Keywords:
Subject headings:Diphosphonates;
Pain;
Alkaline Phosphatase;
Osteoclasts
- From:
Chinese Journal of Tissue Engineering Research
2015;(15):2325-2329
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Bisphosphonates that can suppress osteoclast activity strongly is a powerful inhibitor for bone resorption, which has been reported to have good effects in the treatment of fibrous dysplasia.
OBJECTIVE:To evaluate the clinical effect of surgical treatment combined with bisphosphonate therapy in the treatment of fibrous dysplasia.
METHODS: Fifteen patients with fibrous dysplasia of the long bone were subjected to surgical treatment and oral bisphosphonate therapy postoperatively. Limb pain, limb function, local X-ray manifestations and blood alkaline phosphatase activity were observed before and at 3, 6, 12, 24 months after treatment. The therapeutic effects were evaluated using modified Macnab standards.
RESULTS AND CONCLUSION:Al the 15 patients were folowed up for more than 24 months, and their pain symptoms were significantly relieved after the combined treatment of surgery and bisphosphonates, excelent in 12 cases and effective in 1 case, and the total efficiency was 100%. X-ray films showed that the density slightly decreased in operation areas after 3 months, but at 6 months after treatment, the cortical bone was thickened and the marrow cavity density increased in the operation areas, and non-focal zone was continuously enlarged. No fractures and recurrence were found in al patients. At 6 months after treatment, the serum alkaline phosphatase activity decreased significantly (P < 0.05). The results suggest that surgical operation with bisphosphonate treatment for bone fibrous dysplasia can effectively inhibit the bone resorption, promote bone formation, increase the intensity of the lesion, reduce fractures and recurrence rate, so as to achieve a better therapeutic effect in clinic.
