Study on protective effect and mechanism of caffeic acid phenethylester in rats with doxorubicin-induced myocardial injury
- VernacularTitle:咖啡酸苯乙酯对多柔比星所致心肌损伤大鼠心脏的保护作用及其机制研究
- Author:
Yunjie WANG
;
Jie NING
- Publication Type:Journal Article
- Keywords:
caffeic acid phenethylester;
doxorubicin;
myocardial injury;
oxidative stress
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study protective effect and mechanism of caffeic acid phenethyl ester ( CAPE ) in rats with doxorubicin-induced myocardial injury.Methods Sixty male SD rats were randomly divided into control group, model group and CAPE ( 12、24、48 mg/kg ) groups.The models of doxorubicin-induced myocardial injury were established by injection of 2.5 mg/kg doxorubicin every other day for 6 times.After the last injection, model group was given distilled water and CAPE ( 12、24、48 mg/kg ) groups were fed with CAPE, one time a day for 8 weeks.After consecutive 8 weeks, serum creatine kinase, lactate dehydrogenase and BNP were assessed , NO concentration, MDA,GSH,SOD,NOS,LPO and CAT contents in the heart were determined and histopathological changes were detected.Results serum creatine kinase、lactate dehydrogenase and BNP of CAPE 48 mg/kg group decreased significantly(P<0.05), while the activity of NO,NOS,GSH,CAT and SOD increased in the CAPE 48 mg/kg group significantly ( P<0.05 ) .Histopathology showed caffeic acid phenethyl ester could improve the doxorubicin-induced myocardium injury. Conclusion caffeic acid phenethylester has the protective effects in rats with doxorubicin-induced myocardial injury.Protective effect may be related to improve myocardial against oxidative stress damage.
