Study on the effect of liver function and tumor marker of patients with liver cirrhosis after hepatitis B by nucleoside drugs Entecavir
- VernacularTitle:恩替卡韦对乙型肝炎后肝硬化患者肝功能及肿瘤标志物的影响研究
- Author:
Xingguo XIAO
;
Huili WU
;
Kunkun LI
- Publication Type:Journal Article
- Keywords:
nucleoside analogues;
hepatitis B cirrhosis;
liver function;
tumor markers
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of liver function and tumor markers by nucleoside analogues Entecavir on patients with liver cirrhosis after hepatitis B.Methods 90 patients with liver cirrhosis after hepatitis B were selected, according to the different drugs were divided into experimental group and control group.Liver function and levels of tumor markers were compared after experiment.Results Two groups of patients with male to female ratio, average age, course of disease, no significant difference in general data of hepatitis B virus DNA content, comparable (P>0.05);Compared with the control group, the experimental group HBV DNA level is low, the negative rate was significantly higher (P<0.05);Compared with the control group, the experimental group ALT, AST and TBiL levels were significantly increased(P<0.05), ChE, AlB were significantly decreased (P<0.05);Compared with the control group, the experimental group CEA, AFP, CA125 and lower CA199 levels (P<0.05).Conclusion Nucleoside drugs can significantly improve liver function in patients with liver cirrhosis after hepatitis Band tumor markers indicators, and it is significance for treatment of liver cirrhosis after hepatitis.