Study on the repair effect of mecobalamin in the treatment of spinal cord injury
- VernacularTitle:甲钴胺治疗脊髓损伤后的神经修复作用研究
- Author:
Xiaoguang LIU
;
Xuemin YANG
;
Xu CHEN
- Publication Type:Journal Article
- Keywords:
methylcobalamin;
spinal cord injury;
curative effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):119-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the repair effect of methylcobalamin treatment of nerve after spinal cord injury.Methods 108 cases of patients with acute spinal cord injury were selected treated in our hospital from 2010 April to 2014 April , including 60 cases of male, female 48 cases, were randomly divided into Mecobalamin group(n=56) and control group(n=52), mecobalamin group was treat with a cobalt amine, control group was given conventional treatment (dexamethasone intravenous drip note).According to American spinal cord injury score (ASIA) to set sensory function, motor function and spinal cord function score criteria, observed and record ed the sensory function, motor function, recovery of neurological function and complications the two groups of patients were treated for 6 weeks and followed up for 6 months.Results Spinal cord injury patients after 6 weeks and 6 months follow-up, the improvement of sensory and motor function of mecobalamin group were significantly better than the control group ( P <0.01 );Mecobalamin group patients after first to 3 weeks of recovery of neurological function was higher than those of the control group (P<0.05);the 2 groups were found urinary tract infections, lung infections, vomiting, reaction of ulcer complications, but the difference was not statistically significant ( P>0.05).Conclusion In patients with acute spinal cord injury treated by mecobalamin treatment can improve the nerve function damage condition, improve the prognosis and quality of life.
