Research of Adp and IGF-1 on elderly patients with chronic heart failure by catechin
- VernacularTitle:儿茶素治疗老年慢性心衰患者的临床疗效及其对脂联素、胰岛素样生长因子-1的影响研究
- Author:
Yabin ZHAO
;
Jie GAO
;
Baoyu WANG
;
Yangli SUN
;
Ning YANG
- Publication Type:Journal Article
- Keywords:
catechin;
chronic heart failure;
adiponectin;
insulin like growth factor -1
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):126-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the role of adiponectin, insulin like growth factor -1 in elderly chronic heart failure.Methods 92 elderly patients with chronic heart failure were selected and divided into control group and experiment group.46 cases of the control group were treated with conventional treatment including strong heart, diuresis, vasodilator,lowering blood pressure, the experimental group was on the basis of routine treatment with catechin, 50 mg/kg orally, 1 times a day.2 weeks as a course, 1 course of treatment.Adiponectin, insulin like growth factor -1,BNP,LVEDD, LVESD and LVEF were compared before and after treatment.Results After treatment, the total effective rate of observation group was 93.48%, the control group total effective rate was 76.09%.The total effective rate of observation group was significantly higher than that of the control group (χ2 =5.39, P <0.05 ).After treatment, BNP, Adp in two groups decreased, IGF-1 increased, compared with control group, BNP, Adp level of the experiment group were lower, IGF-1 was higher(P<0.05),and LVEDD and LVESD of the experiment were lower, LVEF was higher, (P<0.05). Conclusion Catechins can decrease the serum levels of adiponectin, elevate insulin like growth factor-1, improve the degree of heart failure, is worthy of clinical application.
