Review on taxanes-induced peripheral neuropathy
- VernacularTitle:紫杉烷类抗肿瘤药物所致外周神经毒性相关研究进展
- Author:
Rui CHEN
;
Guangyu YAO
;
Lujia CHEN
;
Xiaolei HU
;
Changsheng YE
- Publication Type:Journal Article
- Keywords:
taxanes;
peripheral neuropathy;
prevention and treatment
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):185-188
- CountryChina
- Language:Chinese
-
Abstract:
As a tubulin stabilizer, taxanes are widely used in the treatment of breast cancer, ovarian cancer, non-small-cell lung cancer (NSCLC),and part of head and neck malignant tumors, and were confirmed to be significantly effective.However, taxanes-induced peripheral neuropathy(TIPN) still affects the quality of life and psychological status of patients to varying degrees, severe cases can lead to dose reduction, and even chemotherapy interruption.In this paper, we summarize the pathogenesis, risk factors, clinical assessment, the progress of prevention and treatment of TIPN, to provide the basis for the prediction and early prevention of TIPN in the clinical administration, thus we can improve patients’ quality of life while extending their survival.
