Preliminary study of liver targeting interferon on the immune toxicity of mice
- VernacularTitle:肝靶向干扰素对小鼠免疫毒性的初步研究
- Author:
Wenting ZENG
;
Xuemei LU
;
Jie WANG
;
Xiaobao JIN
;
Jiayong ZHU
- Publication Type:Journal Article
- Keywords:
IFN-CSP;
delayed hypersensitivity test;
plaque forming cell assay
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):45-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the immunotoxicity effect of Liver targeting interferon (IFN -CSP) on mice.Methods Mice were randomly divided into five groups:low, middle and high dose of IFN-CSP, solvent control group(saline) and Positive control group (cyclophosphamide).They were injected subcutaneously for 2 weeks.Delayed hypersensitivity test was used to determine the cell immunefunction and plaque forming cell assay was used to determine the humoral immune function.Results There was no significant difference of the the index of immune organ and the ear swelling degree between IFN-CSP groups and control group.There was also no significant difference on hemolytic plaque test between them.Conclusion IFN-CSP has no significant effect on both cellular immunity function and humoral immune function of mice, this results will provides the basis for further safety evaluation.
